United States securities and exchange commission logo

                 June 2, 2022

       Vimal Mehta, Ph.D.
       Chief Executive Officer
       BioXcel Therapeutics, Inc.
       555 Long Wharf Drive
       New Haven, CT 06511

                                                        Re: BioXcel
Therapeutics, Inc.
Statement on Form S-3
                                                            Filed May 27, 2022
                                                            Filed 333-265277

       Dear Dr. Mehta:

              This is to advise you that we have not reviewed and will not
review your registration

               Please refer to Rules 460 and 461 regarding requests for
acceleration. We remind you
       that the company and its management are responsible for the accuracy and
adequacy of their
       disclosures, notwithstanding any review, comments, action or absence of
action by the staff.

              Please contact Michael Davis at 202-551-4385 or Celeste Murphy at
202-551-3257 with
       any questions.


                 Division of Corporation Finance

                 Office of Life Sciences
       cc:                                              Peter N. Handrinos